Swiss TPH Cases of SARS-CoV-2 variant Omicron are surging in numerous settings, with early evidence suggesting Omicron is more infectious than the Delta variant. It is not yet known, however, if Omicron has higher severity or if vaccines are less effective. New research from Swiss TPH now provides guidance to decision-makers on Omicron’s potential public health impact for a range of different scenarios. The paper is currently under review and available as pre-print.